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2 edition of Studies of thyroid angiogenesis and apoptosis found in the catalog.

Studies of thyroid angiogenesis and apoptosis

Vimal Patel

Studies of thyroid angiogenesis and apoptosis

by Vimal Patel

  • 95 Want to read
  • 10 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D) - University of Birmingham, Department of Medicine, Faculty of Medicine and Dentistry.

Statementby Vimal Patel.
ID Numbers
Open LibraryOL18189123M

A few studies have shown that the bioactive components of cruciferous vegetables can have beneficial effects on biomarkers of cancer-related processes in people. For example, one study found that indolecarbinol was more effective than placebo in reducing the growth of .   Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo largely by modulating the apoptosis suppressor proteins and by interfering with the growth factor receptor signaling pathways as exemplified by the EGF‐receptor. To extend these observations made in vitro and to study the Cited by:

This study aims to determine the functional roles of microRNAb-5p (miRb) in the suppression of anaplastic thyroid carcinoma. We used hydration-of-freeze-dried-matrix (HFDM) formulated liposomes (liposome-loaded miRb) for effective delivery of miRb to anaplastic thyroid carcinoma in vitro and in vivo. Real time polymerase chain was used to determine the level of by: 4. Normally, angiogenesis and apoptosis function as the natural regulators of cellular activity, proliferation and programmed cell death. As defined by Harmey (), “angiogenesis is regulated by a network of inducing and inhibiting factors under physiologic conditions, whereas in pathologic conditions, such as regulation is altered or absent” (p).

The thyroid hormone receptor on the integrin mediates the actions of the hormone on tumor cell proliferation5–7,12,26 and on angiogenesis.8,9,12,13 We discuss in this review the significance of the interface of thyroid hormone and cancer cells at integrin αvβ3, interpreted in part by the actions of the deaminated analog of T 4, tetrac, and Cited by: Vascular endothelial growth factor (VEGF) is a mitogen that plays a crucial role in angiogenesis and lymphangiogenesis. It is involved in tumor survival through inducing tumor angiogenesis and by increasing chemoresistance through autocrine signaling. Because of its importance in tumor formation and survival, several medications have been developed to inhibit VEGF and reduce blood vessel Cited by: 1.


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Studies of thyroid angiogenesis and apoptosis by Vimal Patel Download PDF EPUB FB2

A series of reports in the past decade have ascribed pro-angiogenic activity to several thyroid hormone analogues, including L-thyroxine (T 4), 3,5,3-triiodo-L-thyronine (T 3) and diiodothyropropionic acid (DITPA).Model systems of angiogenesis have demonstrated that thyroid hormone-induced neovascularization is initiated at a cell surface receptor for the hormone on an by: Objective: To perform (i) an immunohistochemical investigation of cell proliferation, apoptosis, angiogenesis, and malignancy markers in 15 functioning and 15 nonfunctioning thyroid adenomas, and in normal adjacent tissue, and (ii) a genetic analysis of thyroid-stimulating hormone receptor (TSH-r), Gsα, and RAS mutations in the same group of adenomas, in order to describe their expression Cited by: 8.

Cancer cells display enhanced proliferation, reduced apoptosis and increased angiogenesis owing to both genomic and non-genomic actions of THs [] [] []. L-thyroxine (T 4) is the primary. The principal secretory product of the thyroid gland, L-thyroxine (T 4), is anti-apoptotic at physiological concentrations in a number of cancer cell the mechanisms of anti-apoptosis activated by the hormone are interference with the Ser phosphorylation (activation) of p53 and with TNFα/Fas-induced by: Angiogenesis is dependent upon integrin expression in the plasma membrane of endothelial and vascular smooth muscle cells and results of thyroid hormone studies in the CAM model led to the description of a cell surface receptor for thyroid hormone on integrin αvβ3 (Bergh et al., ).In this model, the proangiogenic thyroid hormone signal was shown to be transduced by mitogen-activated Cited by: Previous studies reported that thyroid hormone not only play a key role to promote cancer cells proliferation but also induces anti-apoptosis.

In breast cancer, the transcription of the pro-apoptotic Bclassociated death promoter (Bad) gene and X-linked inhibitor of apoptosis (XIAP) gene are downregulated by T by: 1.

A fundamental question of how angiogenesis is linked to apoptosis of endothelial cells and of tumor cells is addressed here. The angiogenic switch in a tumor is followed by decreased apoptosis. Tumor growth is angiogenesis-dependent (for experimental evidence see reviews,). In the absence of angiogenesis, tumor growth is restricted to a Cited by:   Blood vessel regression is an essential process for ensuring blood vessel networks function at optimal efficiency and for matching blood supply to the metabolic needs of tissues as they change over time.

Angiogenesis is the major mechanism by which new blood vessels are produced, but the vessel growth associated with angiogenesis must be complemented by remodeling and Cited by: The current study exhibited that miR might represent a potential therapeutic target for patients with thyroid carcinomas having aggressive clinical behaviour.

Keywords: VEGF-A, p53, microRNA, miR, angiogenesis, thyroid by: 3. Introduction. Thyroid cancer is a common endocrine malignancy, the incidence of which shows marked geographic, ethnic and gender variation.According to the WHO classification, thyroid carcinoma has been classified into papillary, follicular, medullary and anaplastic thyroid cancer subtypes differ markedly in terms of etiology, biology, clinical presentation, treatment Cited by: 8.

Thyroid hormone and anti-apoptosis in tumor cells Hung-Yun Lin 1,2, Gennadi V. Glinsky 3, Shaker A. Mousa 4, Paul J. Davis 4,5 1 PhD Program for Cancer Biology and Drug Discovery, College of. In an in vitro study with a number of thyroid cancer cell lines (TPC-1, NPA, SW, and two anaplastic cell lines ARO and FRO), TRAIL triggered significant apoptosis and was more effective than TNF-α and Fas.

Investigation of apoptosis induction via the death-receptor pathway may lead to the development of a distinct group of antineoplastic Cited by: 3.

The recent studies have shown the importance of notch cell-surface receptors and their interaction with various cell membrane ligands in angiogenesis. Abundant angiogenesis in either benign or aggressive pituitary adenomas appears to be generally nonexistent in many of the tumors.

Medullary thyroid cancers (MTC) are rare tumors of neuroendocrine origin that arise from parafollicular C-cells, which secrete a variety of peptides and hormones including calcitonin.

As opposed to the more common papillary and follicular thyroid cancer subtypes, MTC represents a rare and under-characterized form of cancer, and may cause death Cited by: 2.

The transcription of a large number of genes is regulated by this cell surface hormone receptor [35], and many of these are relevant to tumor cell proliferation, to tumor cell survival.

Angiogenesis is the mechanism of blood vessel formation after the first few days of embryogenesis, and is essential for all tissue growth.

In adults, angiogenesis occurs in the thyroid during. For a number of tumors it has been shown that this dormant state is mediated through inhibition of angiogenesis. This dormant state is characterized by normal proliferation, increased apoptosis, and insufficient neovascularization.

Removal of inhibiting antiangiogenic factors leads to growth of Cited by: Apoptosis has emerged as an important process in both carcinogenesis and as the response to anticancer treatments for thyroid tumors.

Thyroid cancer has been associated with alterations in an increasing number of apoptotic molecules. Our knowledge of apoptosis offers hope for better diagnosis, therapy, and staging thyroid by: 3.

Studies of PEMF therapy in human breast cancer and colon cancer cell lines. A study by Crocetti and coworkers 38 investigated whether ultra‐low intensity and frequency PEMF therapy could induce apoptosis in human breast adenocarcinoma cells (MCF7).

PEMF exposure was cytotoxic to MCF7 cells, but not to normal breast epithelial cells (MCF10).Cited by: Chronic infection and inflammation contribute to around 25% of cancer cases worldwide.

While a direct link between several types of human malignancies Cited by:. Thyroid hormone as a regulator of tumor induced angiogenesis Article Literature Review in Cancer letters (2) February with 14 Reads How we measure 'reads'.

Anaplastic Thyroid carcinoma is an extremely aggressive solid tumor that resists most treatments and is almost always fatal. Galectin-3 (Gal-3) is an important marker for thyroid Cited by: 8.Several physiological processes, including cellular growth, embryonic development, differentiation, metabolism and proliferation, are modulated by genomic and nongenomic actions of thyroid hormones (TH).

Several intracellular and extracellular candidate proteins are regulated by THs. 3,3,5-Triiodo-L-thyronine (T3) can interact with nuclear thyroid hormone receptors (TR) to modulate Cited by: 1.